Lost

Lost is a TV reality show about a group of people who survive a plane crash on a mysterious tropical island. The show was created by Jeffrey Lieber, J.J. Abrams and Damon Lindelo.
The show is basically about how the characters survive on the island, but they also have flashbacks. In most episodes, the story line will follow one character, past and present. They will flashback to show a choice the character made in the past (to show how it's affecting the present). Season One described in detail why each passenger was on the doomed flight.
Season One is about how they survive, but has some mysteries with the contents of a hatch, a mysterious creature roaming the jungle, and mysterious people called the 'Others'. (To see a complete listing of episodes in Season One, click here. Warning: Plot and/or ending spoiler.)
Season Two introduces 3 new characters and is played as beginning 44 days after the crash. (To See a complete listing of episodes in Season Two, including plotlines, click here. Warning: Plot and/or ending spoiler.)
Some of the actors and actresses on this show are Evangeline Lilly, Naveen Andrews, and many others.
The numbers 4, 8, 15, 16, 23 and 42 appear many times on Lost, and are used as mysterious numbers, some believed to be cursed.